单细胞转录组测序数据揭示食管鳞状细胞癌细胞外囊泡的遗传来源
核心信息
- 论文英文标题: Single-cell RNA-sequencing data reveals the genetic source of extracellular vesicles in esophageal squamous cell carcinoma
- 期刊: Pharmacol Res
- 发表年份: 2023
- DOI: 10.1016/j.phrs.2023.106800
- PMID/PMCID: 37217040
研究概览
Our study aims to investigate the cellular origin of EVs in ESCC, and unveil the unknown molecular and cellular mechanisms underlying cell-cell communications. Extracellular vesicles (EVs), secreted by most cell types, serve as a critical factor in tumorigenesis via intercellular communications.
核心发现
Esophageal squamous cell carcinoma (ESCC) is invasive cancer and the complex mechanisms underlying carcinogenesis remain unclear.
Extracellular vesicles (EVs), secreted by most cell types, serve as a critical factor in tumorigenesis via intercellular communications.
Our study aims to investigate the cellular origin of EVs in ESCC, and unveil the unknown molecular and cellular mechanisms underlying cell-cell communications.
Six ESCC patients were enrolled and single-cell RNA sequencing (scRNA-seq) analyses were conducted to screen different cell subpopulations.
Echo Biotech 角色
组织外泌体分离鉴定及长链RNA组学 及 组织外泌体&单细胞数据联合分析
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: Tissue EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), Integrated Multi-omics Analysis, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: Single-cell RNA-sequencing data reveals the genetic source of extracellular vesicles in esophageal squamous cell carcinoma Pharmacol Res. 2023. DOI: 10.1016/j.phrs.2023.106800. PMID/PMCID: 37217040.