单囊泡nano-FTIR红外光谱技术在肿瘤恶性诊断中的应用
核心信息
- 论文英文标题: Single-Vesicle Infrared Nanoscopy for Noninvasive Tumor Malignancy Diagnosis
- 期刊: J Am Chem Soc
- 发表年份: 2022
- DOI: 10.1021/jacs.2c07393
- PMID/PMCID: 36288475
研究概览
We employ near-field infrared (nano-FTIR) spectroscopy to investigate malignancy-related protein heterogeneity in a single sEV and demonstrate the discriminability of sEV protein heterogeneity to evaluate tumor malignancy and metastasis. It provides a noninvasive solution to elucidate cancer development and facilitates the exploitation of potential cancer biomarkers.
核心发现
Protein heterogeneity in molecular expression and structures determines tumorigenesis and is the diagnostic and therapeutic cancer biomarker.
Small extracellular vesicles (sEVs) are cell-released nanoscaled membrane-bound vesicles transferring bioactive molecules for intercellular communication and playing essential roles in tumor progression and metastasis.
Therefore, protein heterogeneity in tumor-derived sEVs indicates the degree of malignant transformation, providing a noninvasive biomarker for cancer diagnosis and malignancy evaluation.
We employ near-field infrared (nano-FTIR) spectroscopy to investigate malignancy-related protein heterogeneity in a single sEV and demonstrate the discriminability of sEV protein heterogeneity to evaluate tumor malignancy and metastasis.
Echo Biotech 角色
2例乳腺癌组织外泌体分离
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: Tissue EV Isolation & Purification, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: Single-Vesicle Infrared Nanoscopy for Noninvasive Tumor Malignancy Diagnosis J Am Chem Soc. 2022. DOI: 10.1021/jacs.2c07393. PMID/PMCID: 36288475.