毛囊神经嵴干细胞衍生sEV通过TGF-β/SMAD/HAS2途径增强神经束膜细胞增殖和迁移

核心信息

  • 论文英文标题: Small extracellular vesicles derived from hair follicle neural crest stem cells enhance perineurial cell proliferation and migration via the TGF-β/SMAD/HAS2 pathway
  • 期刊: Neural Regen Res
  • 发表年份: 2025
  • DOI: 10.4103/NRR.NRR-D-25-00127
  • PMID/PMCID: 40903975; PMC12694726

研究概览

The present study therefore focuses on small extracellular vesicles derived from hair follicle neural crest stem cells, which preserve the bioactive properties of the parent cells while avoiding the transplantation-associated risks. These results provide new insights into peripheral nerve regeneration from the perspective of perineurial cells, and present a novel approach for the clinical treatment of peripheral nerve defects.

核心发现

03/01300535-202605000-00040/figure1/v/2025-10-21T121913Z/r/image-tiff Peripheral nerve defect repair is a complex process that involves multiple cell types; perineurial cells play a pivotal role.

Hair follicle neural crest stem cells promote perineurial cell proliferation and migration via paracrine signaling; however, their clinical applications are limited by potential risks such as tumorigenesis and xenogeneic immune rejection, which are similar to the risks associated with other stem cell transplantations.

The present study therefore focuses on small extracellular vesicles derived from hair follicle neural crest stem cells, which preserve the bioactive properties of the parent cells while avoiding the transplantation-associated risks.

In vitro, small extracellular vesicles derived from hair follicle neural crest stem cells significantly enhanced the proliferation, migration, tube formation, and barrier function of perineurial cells, and subsequently upregulated the expression of tight junction proteins.

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关联平台: Echosome®, Research Reagents & Tools

关联服务与能力: Small RNA / Cargo Loading, Research Reagent / Product Supply

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参考文献

原始论文: Small extracellular vesicles derived from hair follicle neural crest stem cells enhance perineurial cell proliferation and migration via the TGF-β/SMAD/HAS2 pathway Neural regeneration research. 2025. DOI: 10.4103/NRR.NRR-D-25-00127. PMID/PMCID: 40903975; PMC12694726.