CD74信号的空间下调可能驱动部分实体肺腺癌的侵袭性成分发展

核心信息

• 论文英文标题: Spatial downregulation of CD74 signatures may drive invasive component development in part-solid lung adenocarcinoma
• 期刊: iScience
• 发表年份: 2023
• DOI: 10.1016/j.isci.2023.107699
• PMID/PMCID: 37810252; PMC10550719

研究概览

Pulmonary nodules with part-solid imaging features manifest during the progression from preinvasive to invasive lung adenocarcinoma. Higher immune infiltration was observed among MC1 regions in ST profiles, and further analysis revealed that macrophages may be involved in this process through the CD74 axis.

核心发现

Pulmonary nodules with part-solid imaging features manifest during the progression from preinvasive to invasive lung adenocarcinoma.

To define the spatial composition and evolutionary trajectories of early-stage lung adenocarcinoma, we combined spatial transcriptomics (ST) and pathological annotations from 20 part-solid nodules (PSNs), four of which were matched with single-cell RNA sequencing.

Two malignant cell populations (MC1 and MC2) were identified, and a linear evolutionary relationship was observed.

Compared to MC2, the pre-existing malignant MC1 exhibited a lower metastatic signature, corresponding to the preinvasive component (lepidic) on pathology and the ground glass component on PSN imaging.

Echo Biotech 角色

单细胞转录组+空间转录组及联合分析

关联平台: Exoomics®

关联服务与能力: Single-Cell RNA Sequencing, Spatial Transcriptomics, Integrated Multi-omics Analysis

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Spatial downregulation of CD74 signatures may drive invasive component development in part-solid lung adenocarcinoma iScience. 2023. DOI: 10.1016/j.isci.2023.107699. PMID/PMCID: 37810252; PMC10550719.