来自暴露于二氧化硅的巨噬细胞外泌体的 SPP1 触发成纤维细胞转分化

核心信息

  • 论文英文标题: SPP1 derived from silica-exposed macrophage exosomes triggers fibroblast transdifferentiation
  • 期刊: Toxicol Appl Pharm
  • 发表年份: 2021
  • DOI: 10.1016/j.taap.2021.115559
  • PMID/PMCID: 33961903

研究概览

To explore the role of exosomal proteins in the occurrence and development of silicosis and the possible intervention targets, this study conducted proteomic analysis of macrophage-derived exosomes induced by silica, to identify specific proteins for intervention. Including inflammatory changes reduced by macrophages and phenotypic transdifferentiation reduced by lung fibroblasts.

核心发现

The occurrence and development of silicosis is related to the interaction of multiple cells through signal transmission caused by silica dust.

Including inflammatory changes reduced by macrophages and phenotypic transdifferentiation reduced by lung fibroblasts.

As a communication medium between cells, exosomes have become a hot research topic.

To explore the role of exosomal proteins in the occurrence and development of silicosis and the possible intervention targets, this study conducted proteomic analysis of macrophage-derived exosomes induced by silica, to identify specific proteins for intervention.

Echo Biotech 角色

Echo Biotech contributed EV isolation and purification; the study also used or cited Exosupur®.

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: EV Isolation & Purification, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: SPP1 derived from silica-exposed macrophage exosomes triggers fibroblast transdifferentiation Toxicol Appl Pharm. 2021. DOI: 10.1016/j.taap.2021.115559. PMID/PMCID: 33961903.