滑膜组织外泌体通过 NF-κB 信号通路诱导软骨细胞炎症和降解

核心信息

• 论文英文标题: Synovial tissue-derived extracellular vesicles induce chondrocyte inflammation and degradation via NF-κB signalling pathway: An in vitro study
• 期刊: J Cell Mol Med
• 发表年份: 2022
• DOI: 10.1111/jcmm.17227
• PMID/PMCID: 35179308; PMC8980928

研究概览

Osteoarthritis (OA) is a whole-joint disease characterized by synovial inflammation and cartilage degeneration. However, the relationship between synovial inflammation and cartilage degeneration remains unclear.

核心发现

Osteoarthritis (OA) is a whole-joint disease characterized by synovial inflammation and cartilage degeneration.

However, the relationship between synovial inflammation and cartilage degeneration remains unclear.

The modified Hulth's method was adopted to establish a knee OA (KOA) rabbit model.

Synovial tissue was collected after 8 weeks, and synovial tissue-derived extracellular vesicles (ST-EVs) were extracted by filtration combined with size exclusion chromatography (SECF), followed by identification through transmission electron microscopy (TEM), nanoparticle tracer analysis (NTA) and Western blot (WB).

Echo Biotech 角色

Echo Biotech contributed EV isolation and purification; the study also used or cited Exosupur®.

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: EV Isolation & Purification, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Synovial tissue-derived extracellular vesicles induce chondrocyte inflammation and degradation via NF-κB signalling pathway: An in vitro study J Cell Mol Med. 2022. DOI: 10.1111/jcmm.17227. PMID/PMCID: 35179308; PMC8980928.