心肌缺血再灌注损伤后通过IMTP修饰的牛奶外泌体靶向递送miR-146a通过抑制NF-κB信号通路发挥心脏保护作用

核心信息

• 论文英文标题: Targeting delivery of miR-146a via IMTP modified milk exosomes exerted cardioprotective effects by inhibiting NF-κB signaling pathway after myocardial ischemia-reperfusion injury
• 期刊: J Nanobiotechnol
• 发表年份: 2024
• DOI: 10.1186/s12951-024-02631-0
• PMID/PMCID: 38951872; PMC11218161

研究概览

In this study, the effects of miR-146a containing MEs (MEs-miR-146a) on improvement of cardiac function were examined in a rat model of MIRI. Taken together, our findings suggested miR-146a containing MEs may be a promising strategy for the treatment of MIRI with better outcome after modification with ischemic myocardium-targeted peptide, which was expected to be applied in clinical practice in future.

核心发现

Reperfusion therapy is critical for saving heart muscle after myocardial infarction, but the process of restoring blood flow can itself exacerbate injury to the myocardium.

This phenomenon is known as myocardial ischemia-reperfusion injury (MIRI), which includes oxidative stress, inflammation, and further cell death.

microRNA-146a (miR-146a) is known to play a significant role in regulating the immune response and inflammation, and has been studied for its potential impact on the improvement of heart function after myocardial injury.

However, the delivery of miR-146a to the heart in a specific and efficient manner remains a challenge as extracellular RNAs are unstable and rapidly degraded.

Echo Biotech 角色

IMTP脂锚

关联平台: Echosome®, Research Reagents & Tools

关联服务与能力: Targeting Peptide / Surface Modification, Research Reagent / Product Supply

关联产品或试剂: ExoBrooch™ Targeting Peptide/Lipid Anchor Kit

参考文献

原始论文: Targeting delivery of miR-146a via IMTP modified milk exosomes exerted cardioprotective effects by inhibiting NF-κB signaling pathway after myocardial ischemia-reperfusion injury Journal of nanobiotechnology. 2024. DOI: 10.1186/s12951-024-02631-0. PMID/PMCID: 38951872; PMC11218161.