靶向sEVs中的网状素4（RTN4）可抑制转移并增强三阴性乳腺癌的免疫治疗效果

核心信息

• 论文英文标题: Targeting Reticulin 4 (RTN4) Within Small Extracellular Vesicles Combats Metastasis and Reinforces Immunotherapy in Triple-Negative Breast Cancer
• 期刊: J Extracell Vesicles
• 发表年份: 2025
• DOI: 10.1002/jev2.70154
• PMID/PMCID: 40831287; PMC12365394

研究概览

In this study, we isolated sEV from non-metastatic and metastatic TNBC plasma samples. sEV protein RTN4 is a potential new prognostic marker for non-invasive detection of TNBC and a new target for TNBC treatment.

核心发现

Small extracellular vesicles (sEV) are a class of natural vesicles rich in heterogeneous cargos with the great advantage of non-invasive detection; these vesicles exhibit complex intercellular crosstalk and mediate important biological functions.

However, the potential value of plasma sEV in clinical prognosis prediction of triple-negative breast cancer (TNBC) and their biological functions have not been well elucidated.

In this study, we isolated sEV from non-metastatic and metastatic TNBC plasma samples.

We found that the expression of reticulin 4 (RTN4) in metastatic patients was significantly higher than that in non-metastatic patients.

Echo Biotech 角色

Exospupur ES914分离血浆EVs

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Biofluid EV Isolation & Purification, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Targeting Reticulin 4 (RTN4) Within Small Extracellular Vesicles Combats Metastasis and Reinforces Immunotherapy in Triple-Negative Breast Cancer Journal of Extracellular Vesicles. 2025. DOI: 10.1002/jev2.70154. PMID/PMCID: 40831287; PMC12365394.