三叶青通过sEV介导的星形胶质细胞-小胶质细胞间通讯抑制HSPB1 Akt NF-κB信号传导缓解热性惊厥
核心信息
- 论文英文标题: Tetrastigma hemsleyanum alleviates febrile seizures by inhibiting HSPB1/Akt/NF-κB signaling via small extracellular vesicle-mediated astrocyte-microglia crosstalk
- 期刊: Phytomedicine
- 发表年份: 2026
- DOI: 10.1016/j.phymed.2026.158087
- PMID/PMCID: 41886953
研究概览
We found pretreatment with total flavonoids from T. Our results suggest FTH may alleviate FS by inhibiting the hippocampal HSPB1/Akt/NF-κB signaling pathway, which might initially be triggered by the release of sEVs from astrocytes to microglia.
核心发现
We found pretreatment with total flavonoids from T.
hemsleyanum (FTH) containing 36 components could inhibit FS in rats.
Microglia and astrocytes emerged as the two most prominent cell populations exhibiting significantly elevated heat shock protein B1 (Hspb1) gene expression after FS in the scRNA-seq data.
The inflammation-related microglial E subset was enriched in the FS model (MD) group and was associated with the response to heat and the MAPK signaling pathway.
研究设计
We found pretreatment with total flavonoids from T.
hemsleyanum (FTH) containing 36 components could inhibit FS in rats.
Microglia and astrocytes emerged as the two most prominent cell populations exhibiting significantly elevated heat shock protein B1 (Hspb1) gene expression after FS in the scRNA-seq data.
Echo Biotech 角色
大鼠海马组织解离上清外泌体分离鉴定&长链RNA测序&蛋白质组&单细胞联合分析&Exosupur排阻柱ES914
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: Tissue EV Isolation & Purification, Cell-Culture Supernatant EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV lncRNA/mRNA Sequencing, EV Proteomics, Integrated Multi-omics Analysis, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: Tetrastigma hemsleyanum alleviates febrile seizures by inhibiting HSPB1/Akt/NF-κB signaling via small extracellular vesicle-mediated astrocyte-microglia crosstalk Phytomedicine. 2026. DOI: 10.1016/j.phymed.2026.158087. PMID/PMCID: 41886953.