通过外泌体同时递送神经生长因子 mRNA 和蛋白质对脑缺血的治疗效果

核心信息

• 论文英文标题: Therapeutic Effects of Simultaneous Delivery of Nerve Growth Factor mRNA and Protein via Exosomes on Cerebral Ischemia
• 期刊: Mol Ther Nucl Acids
• 发表年份: 2020
• DOI: 10.1016/j.omtn.2020.06.013
• PMID/PMCID: 32682291; PMC7365960

研究概览

In this study, we engineered the exosomes with RVG peptide on the surface for neuron targeting and loaded NGF into exosomes simultaneously, with the resultant exosomes denoted as NGF@ExoRVG. Moreover, the strategy proposed in our study may shed light on the clinical application of other neurotrophic factors for central nervous system diseases.

核心发现

Stroke is the leading neurological cause of death and disability all over the world, with few effective drugs.

Nerve growth factor (NGF) is well known for its multifaceted neuroprotective functions post-ischemia.

However, the lack of an efficient approach to systemically deliver bioactive NGF into ischemic region hinders its clinical application.

In this study, we engineered the exosomes with RVG peptide on the surface for neuron targeting and loaded NGF into exosomes simultaneously, with the resultant exosomes denoted as NGF@ExoRVG.

Echo Biotech 角色

Echo Biotech's specific contribution should be verified from the full text or internal project record.

关联平台: To Be Verified

关联服务与能力: Role Not Identified

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Therapeutic Effects of Simultaneous Delivery of Nerve Growth Factor mRNA and Protein via Exosomes on Cerebral Ischemia Mol Ther Nucl Acids. 2020. DOI: 10.1016/j.omtn.2020.06.013. PMID/PMCID: 32682291; PMC7365960.