组织EVs定义肾细胞癌诊断生物标志物
核心信息
- 论文英文标题: Tissue-Derived Extracellular Vesicles Define Diagnostic Biomarkers for Renal Cell Carcinoma
- 期刊: J Extracell Vesicles
- 发表年份: 2026
- DOI: 10.1002/jev2.70221
- PMID/PMCID: 41656939; PMC12884001
研究概览
Tissue-derived extracellular vesicles (Ti-EVs) play a crucial role in tumour progression, but their value as differential diagnostic markers for various renal cell carcinoma (RCC) subtypes remains uncertain. 1 for chromophobe RCC (chRCC); NDUFA4L2, SERPINA1, VEGFA, EGLN3, CPE and C6orf223 for low-grade clear cell RCC (low-grade ccRCC); and NDUFA4L2, APOC1, TGFBI and LINC00887 for high-grade ccRCC (high-grade ccRCC).
核心发现
Tissue-derived extracellular vesicles (Ti-EVs) play a crucial role in tumour progression, but their value as differential diagnostic markers for various renal cell carcinoma (RCC) subtypes remains uncertain.
1 for chromophobe RCC (chRCC); NDUFA4L2, SERPINA1, VEGFA, EGLN3, CPE and C6orf223 for low-grade clear cell RCC (low-grade ccRCC); and NDUFA4L2, APOC1, TGFBI and LINC00887 for high-grade ccRCC (high-grade ccRCC).
874 for high-grade ccRCC detection was achieved, respectively, using urinary EVs.
Furthermore, integrating single-cell sequencing data revealed that SERPINA1 and VEGFA in low-grade ccRCC, and APOC1 and TGFBI in high-grade ccRCC, were derived from tumour-associated macrophages, whereas NDUFA4L2 originated from cancer cells in both low- and high-grade ccRCC.
Echo Biotech 角色
组织外泌体长链和组织长链RNA测序分析
关联平台: Exoomics®
关联服务与能力: EV lncRNA/mRNA Sequencing
关联产品或试剂: 无明确产品引用
参考文献
原始论文: Tissue-Derived Extracellular Vesicles Define Diagnostic Biomarkers for Renal Cell Carcinoma Journal of extracellular vesicles. 2026. DOI: 10.1002/jev2.70221. PMID/PMCID: 41656939; PMC12884001.