TLyp-1修饰外泌体介导circRAPGEF5 ASO递送通过调节miR-570-3p/SPP1轴抑制肺腺癌转移

核心信息

• 论文英文标题: TLyp-1-modified exosome–mediated delivery of circRAPGEF5 ASO inhibits lung adenocarcinoma metastasis via regulating the miR-570-3p/SPP1 axis
• 期刊: Mater Today Bio
• 发表年份: 2025
• DOI: 10.1016/j.mtbio.2025.102416
• PMID/PMCID: 41209704; PMC12593693

研究概览

This study clarified the mechanism of tLyp-1-EXO-circRAPGEF5 ASO in inhibiting LUAD metastasis, indicating that circRAPGEF5 may serve as a new intervention target for LUAD metastasis. Consequently, using engineered exosomal preparations of circular RNAs for delivery into tumor cells represents a safe and effective strategy for cancer treatment.

核心发现

Exosome circRAPGEF5 promotes lung adenocarcinoma (LUAD) metastasis and may serve as an intervention target, but its mechanism of action is unclear.

Consequently, using engineered exosomal preparations of circular RNAs for delivery into tumor cells represents a safe and effective strategy for cancer treatment.

The results confirmed the successful construction of tLyp-1-exosome (EXO)-circRAPGEF5 antisense oligonucleotides (ASO).

tLyp-1 modified exosomes efficiently targeted LUAD tumors in vivo and in vitro.

Echo Biotech 角色

293F外泌体蛋白外载+电穿孔负载ASO+分离表征+DLS稳定性实验

关联平台: Exoomics®, Echosome®

关联服务与能力: EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), Small RNA / Cargo Loading

关联产品或试剂: 无明确产品引用

参考文献

原始论文: TLyp-1-modified exosome–mediated delivery of circRAPGEF5 ASO inhibits lung adenocarcinoma metastasis via regulating the miR-570-3p/SPP1 axis Materials Today Bio. 2025. DOI: 10.1016/j.mtbio.2025.102416. PMID/PMCID: 41209704; PMC12593693.