超声引导下的功能性EVs用于可视化、可控和高效的肾脏输送以增强肾脏修复

核心信息

• 论文英文标题: Ultrasound-Guided Functionalized Extracellular Vesicles for Visualized, Controlled, and Efficient Renal Delivery for Enhanced Kidney Repair
• 期刊: Adv Healthc Mater
• 发表年份: 2025
• DOI: 10.1002/adhm.202404719
• PMID/PMCID: 40183711

研究概览

This study aims to engineer ultrasound-guided microbubble-functionalized EVs (MB-EVs) via an RGD-integrin connection for visualized, controlled, and efficient renal delivery. However, their efficacy is limited by inefficient delivery.

核心发现

Mesenchymal stem cell-derived extracellular vesicles (EVs) hold great promise for the treatment of acute kidney injury (AKI).

However, their efficacy is limited by inefficient delivery.

Current studies largely focus on increasing the proportion of EVs reaching renal cells, with less emphasis on enhancing the uptake capacity of damaged cells.

In AKI, tubular cells exhibit reduced EV uptake owing to cisplatin damage.

Echo Biotech 角色

Exosupur® ES933分离HuMSC外泌体

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: EV Isolation & Purification, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Ultrasound-Guided Functionalized Extracellular Vesicles for Visualized, Controlled, and Efficient Renal Delivery for Enhanced Kidney Repair Advanced healthcare materials. 2025. DOI: 10.1002/adhm.202404719. PMID/PMCID: 40183711.