年轻脑组织EVs负载GelMA水凝胶通过调节衰老和线粒体功能促进老年皮肤无瘢痕伤口愈合

核心信息

• 论文英文标题: Youthful Brain-Derived Extracellular Vesicle-Loaded GelMA Hydrogel Promotes Scarless Wound Healing in Aged Skin by Modulating Senescence and Mitochondrial Function
• 期刊: Research
• 发表年份: 2025
• DOI: 10.34133/research.0644
• PMID/PMCID: 40161249; PMC11951976

研究概览

In light of this, we identified youthful brain-derived extracellular vesicles (YBEVs) and created a composite GelMA hydrogel material that encourages scarless wound healing in aged skin. In conclusion, the findings suggest that maintaining a youthful brain could potentially alleviate skin aging, and the proposed YBEVs-GelMA hydrogel emerges as a promising strategy for addressing age-related impairments in skin healing.

核心发现

Slow wound healing in the elderly has attracted much attention recently due to the associated infection risks and decreased longevity.

The "brain-skin axis" theory suggests that abnormalities in the brain and nervous system can lead to skin degeneration because abnormal mental states, like chronic stress, can have negative physiological and functional effects on the skin through a variety of processes, resulting in delayed wound healing and accelerated skin aging.

However, it remains unclear whether maintaining a youthful brain has beneficial effects on aged skin healing.

In light of this, we identified youthful brain-derived extracellular vesicles (YBEVs) and created a composite GelMA hydrogel material that encourages scarless wound healing in aged skin.

Echo Biotech 角色

组织外泌体DIA蛋白质组

关联平台: Exoomics®

关联服务与能力: EV Proteomics

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Youthful Brain-Derived Extracellular Vesicle-Loaded GelMA Hydrogel Promotes Scarless Wound Healing in Aged Skin by Modulating Senescence and Mitochondrial Function Research. 2025. DOI: 10.34133/research.0644. PMID/PMCID: 40161249; PMC11951976.