Brown Adipose Tissue-Derived sEV-lncRNA Morrbid Contributes to Cold Acclimation-Induced Cardioprotection Against Extreme Cold
Quick Facts
- Publication title: Brown Adipose Tissue-Derived sEV-lncRNA Morrbid Contributes to Cold Acclimation-Induced Cardioprotection Against Extreme Cold
- Journal: J Lipid Res
- Year: 2026
- DOI: 10.1016/j.jlr.2026.101082
- PMID/PMCID: 42320571
Research overview
This study investigated whether brown adipose tissue (BAT)-derived extracellular vesicles (BAT-EVs) contribute to CA-induced cardioprotection. These vesicles serve as an important mechanism to confer remote cardioprotection, potentially by upregulating cardiac Serpine1 and suppressing apoptosis, highlighting a potential therapeutic strategy for cold-induced injury.
Key findings
CA preserved cardiac function and integrity under -25 °C stress, and these effects were abolished by iBAT ablation.
EVs from CA mice mediate this protection by mitigating cardiomyocyte apoptosis.
Mechanistically, lncRNA Morrbid was enriched in iBAT and serum EVs after CA.
iBAT-specific Morrbid knockdown significantly attenuates EV-mediated protection.
Study design
Mice were subjected to CA or acute cold stress.
Cardiac function was assessed using echocardiography and biomarkers.
Interscapular BAT (iBAT) ablation has confirmed the necessity of iBAT.
Echo Biotech Role
Echo Biotech contributed lncRNA/mRNA sequencing.
Related platforms: Exoomics®
Related services and capabilities: EV lncRNA/mRNA Sequencing
References
Original publication: Brown Adipose Tissue-Derived sEV-lncRNA Morrbid Contributes to Cold Acclimation-Induced Cardioprotection Against Extreme Cold Journal of lipid research. 2026. DOI: 10.1016/j.jlr.2026.101082. PMID/PMCID: 42320571.