Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles

Quick Facts

• Publication title: Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles
• Journal: Nat Commun
• Year: 2025
• DOI: 10.3724/abbs.2024193
• PMID/PMCID: 39949198; PMC12247129

Research overview

Myocardial infarction leads to cardiomyocyte loss, and the compromised proliferative capacity of cardiomyocytes after birth hinders the process of heart repair, ultimately culminating in heart failure. This finding reveals a potential underlying mechanism for the compromised proliferative capacity of cardiomyocytes in adult mice.

Key findings

Myocardial infarction leads to cardiomyocyte loss, and the compromised proliferative capacity of cardiomyocytes after birth hinders the process of heart repair, ultimately culminating in heart failure.

Extracellular vesicles (EVs), known as cell-secreted "messengers", play a pivotal role in tissue pathophysiology.

Here, we report the novel finding that myocardial tissue-derived vesicles from mice on postnatal day 8 (P8-EVs) possess the potential to modulate cardiomyocyte proliferation.

Notably, direct administration of EVs derived from day 1 or day 8 (P1/P8) myocardial tissue does not impact neonatal cardiomyocyte proliferation or myocardial repair in mice with myocardial infarction.

Echo Biotech Role

Echo Biotech contributed EV proteomics.

Related platforms: Exoomics®

Related services and capabilities: EV Proteomics

References

Original publication: Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles Nature communications. 2025. DOI: 10.3724/abbs.2024193. PMID/PMCID: 39949198; PMC12247129.