De-ubiquitinase USP35 promotes peritoneal dissemination of gastric cancer by regulating metabolic reprogramming
Quick Facts
- Publication title: De-ubiquitinase USP35 promotes peritoneal dissemination of gastric cancer by regulating metabolic reprogramming
- Journal: Cell Death Dis
- Year: 2025
- DOI: 10.1038/s41419-025-08322-4
- PMID/PMCID: 41372134; PMC12706015
Research overview
The aim of this study was to identify the mechanism by which USP35 promotes the formation of the pre-peritoneal-metastasis adaptive microenvironment of GC and to find potential therapeutic targets. USP35 expression is the highest in MKN-45P, which is closely related to its high peritoneal metastasis potential.
Key findings
The enhanced adhesion between gastric cancer (GC) cells and peritoneal mesothelial cells (PMCs) is one of the key factors in the formation of the pre-peritoneal-metastasis adaptive microenvironment.
USP35 belongs to the ubiquitin-specific protease family and is involved in regulating the occurrence and progression of various diseases.
However, whether this gene can regulate the adhesion of GC cells to PMCs has not been clarified.
The aim of this study was to identify the mechanism by which USP35 promotes the formation of the pre-peritoneal-metastasis adaptive microenvironment of GC and to find potential therapeutic targets.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification, EV characterization, EV proteomics.
Related platforms: Exoomics®
Related services and capabilities: EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV Proteomics
References
Original publication: De-ubiquitinase USP35 promotes peritoneal dissemination of gastric cancer by regulating metabolic reprogramming Cell death & disease. 2025. DOI: 10.1038/s41419-025-08322-4. PMID/PMCID: 41372134; PMC12706015.