Engineered extracellular vesicles from human placental mesenchymal stem cells attenuate abdominal aortic aneurysm formation by inhibiting Nat10-mediated vascular smooth muscle cell senescence

Quick Facts

  • Publication title: Engineered extracellular vesicles from human placental mesenchymal stem cells attenuate abdominal aortic aneurysm formation by inhibiting Nat10-mediated vascular smooth muscle cell senescence
  • Journal: Biomaterials
  • Year: 2026
  • DOI: 10.1016/j.biomaterials.2026.124109
  • PMID/PMCID: 41791327

Research overview

Human placental mesenchymal stem cell-derived extracellular vesicles (hPMSC-EVs) have demonstrated anti-senescence effects across various diseases. However, their role in abdominal aortic aneurysm (AAA), a degenerative aortic pathology, remains unexplored.

Key findings

Human placental mesenchymal stem cell-derived extracellular vesicles (hPMSC-EVs) have demonstrated anti-senescence effects across various diseases.

However, their role in abdominal aortic aneurysm (AAA), a degenerative aortic pathology, remains unexplored.

Our findings demonstrated that hPMSC-EVs effectively delay vascular smooth muscle cell (VSMC) senescence.

In vivo, modification of hPMSC-EVs with an osteopontin(OPN)-targeted peptide facilitated precise homing to aneurysmal sites and improved local retention.

Echo Biotech Role

Echo Biotech contributed targeting-peptide/surface modification, custom synthesis or technical co-development; the study also used or cited ExoBrooch™.

Related platforms: Echosome®, Research Reagents & Tools

Related services and capabilities: Targeting Peptide / Surface Modification, Custom Ligand / Peptide-Lipid Synthesis, Research Reagent / Product Supply

Related products or reagents: ExoBrooch™ Targeting Peptide/Lipid Anchor Kit

References

Original publication: Engineered extracellular vesicles from human placental mesenchymal stem cells attenuate abdominal aortic aneurysm formation by inhibiting Nat10-mediated vascular smooth muscle cell senescence Biomaterials. 2026. DOI: 10.1016/j.biomaterials.2026.124109. PMID/PMCID: 41791327.