miRNAs derived from plasma small extracellular vesicles predict organo-tropic metastasis of gastric cancer

Quick Facts

  • Publication title: miRNAs derived from plasma small extracellular vesicles predict organo-tropic metastasis of gastric cancer
  • Journal: Gastric Cancer
  • Year: 2022
  • DOI: 10.1007/s10120-021-01267-5
  • PMID/PMCID: 35031872; 6506189

Research overview

Biomarkers for GC's organo-tropic metastasis remained largely unknown, which was investigated in this study from the perspective of small extracellular vesicle (sEV)-derived miRNAs. Additionally, we explored these seven biomarker miRNAs' impact on GC's in vitro motility and discussed their potential involvement in cancer-related biological processes and pathways.

Key findings

The expression profiles of sEV-miRNAs varied greatly across different metastatic patterns.

Based on logistic regression models, we constructed signatures for M0 (hsa-miR-186-5p/hsa-miR-200c-3p/hsa-miR-429/hsa-miR-5187-5p/hsa-miR-548ae-5p), PM (hsa-miR-200c-3p/hsa-miR-429), HM (hsa-miR-200c-3p/hsa-miR-429) and dLNM (hsa-miR-324-5p/hsa-miR-374a-5p/hsa-miR-429/hsa-miR-548ae-5p).

002 for prognostic diversity).

Additionally, we explored these seven biomarker miRNAs' impact on GC's in vitro motility and discussed their potential involvement in cancer-related biological processes and pathways.

Study design

Plasma from treatment-naïve GC patients including no metastasis (M0), peritoneal metastasis (PM), hepatic metastasis (HM) and distant lymph node metastasis (dLNM)) were divided into one discovery (N = 40), one training (N = 40) and one validating cohort (N = 86), then assessed by sEV-miRNA-sequencing and sEV-miRNA-qPCR.

Functional explorations were also performed for verification.

Echo Biotech Role

Echo Biotech's specific contribution should be verified from the full text or internal project record.

Related platforms: To Be Verified

References

Original publication: miRNAs derived from plasma small extracellular vesicles predict organo-tropic metastasis of gastric cancer Gastric Cancer. 2022. DOI: 10.1007/s10120-021-01267-5. PMID/PMCID: 35031872; 6506189.