Multitargeted Immunomodulatory Therapy for Viral Myocarditis by Engineered Extracellular Vesicles

Quick Facts

  • Publication title: Multitargeted Immunomodulatory Therapy for Viral Myocarditis by Engineered Extracellular Vesicles
  • Journal: ACS Nano
  • Year: 2024
  • DOI: 10.1021/acsnano.3c05847
  • PMID/PMCID: 38232382

Research overview

Therefore, we developed cardiac-targeting peptide (CTP) and platelet membrane (PM)-engineered M2 EVs enriched with viral macrophage inflammatory protein-II (vMIP-II), termed CTP/PM-M2 EVsvMIP-II-Lamp2b, to improve the delivery of EVs "cargo" to the heart tissues. Taken together, our findings suggest that CTP-and-PM-engineered M2 EVsvMIP-II-Lamp2b represent an effective means for treating VM and show promise for clinical applications.

Key findings

Immune regulation therapies are considered promising for treating classically activated macrophage (M1)-driven viral myocarditis (VM).

Alternatively, activated macrophage (M2)-derived extracellular vesicles (M2 EVs) have great immunomodulatory potential owing to their ability to reprogram macrophages, but their therapeutic efficacy is hampered by insufficient targeting capacity in vivo.

Therefore, we developed cardiac-targeting peptide (CTP) and platelet membrane (PM)-engineered M2 EVs enriched with viral macrophage inflammatory protein-II (vMIP-II), termed CTP/PM-M2 EVsvMIP-II-Lamp2b, to improve the delivery of EVs "cargo" to the heart tissues.

In a mouse model of VM, the intravenously injected CTP/PM-M2 EVsvMIP-II-Lamp2b could be carried into the myocardium via CTP, PM, and vMIP-II.

Echo Biotech Role

Echo Biotech contributed EV isolation and purification; the study also used or cited Exosupur®.

Related platforms: Exoomics®, Research Reagents & Tools

Related services and capabilities: EV Isolation & Purification, Research Reagent / Product Supply

Related products or reagents: Exosupur® EV Isolation/Purification Kit

References

Original publication: Multitargeted Immunomodulatory Therapy for Viral Myocarditis by Engineered Extracellular Vesicles ACS Nano. 2024. DOI: 10.1021/acsnano.3c05847. PMID/PMCID: 38232382.