Potential Resistance to Antineoplastic Aminated Fullerenes Mediated by M2-Like Monocyte-Derived Exosomes
Quick Facts
- Publication title: Potential Resistance to Antineoplastic Aminated Fullerenes Mediated by M2-Like Monocyte-Derived Exosomes
- Journal: FRONT ONCOL
- Year: 2022
- DOI: 10.3389/fonc.2022.779939
- PMID/PMCID: 35433481; PMC9009388
Research overview
Exosomes are small extracellular vesicles critical for intercellular signaling via their delivery of cargoes, including proteins, DNA, RNA, lipids, and metabolites. Notably, C70-EDA-induced M2-like monocytes released exosomes that triggered the proliferation of recipient tumor cells, which may alleviate the antineoplastic efficacy of C70-EDA.
Key findings
Exosomes are small extracellular vesicles critical for intercellular signaling via their delivery of cargoes, including proteins, DNA, RNA, lipids, and metabolites.
Exosomes play essential roles in remodeling the tumor microenvironment (TME) for tumor growth, metastasis, and drug resistance.
, C70-ethylenediamine [EDA]) exhibit antineoplastic effects by targeting multiple functional proteins.
Nanosized C70-EDA with positive surface charges tends to be taken up by monocytes in the bloodstream and monocyte-derived macrophages in the TME.
Echo Biotech Role
Echo Biotech contributed EV proteomics.
Related platforms: Exoomics®
Related services and capabilities: EV Proteomics
References
Original publication: Potential Resistance to Antineoplastic Aminated Fullerenes Mediated by M2-Like Monocyte-Derived Exosomes FRONT ONCOL. 2022. DOI: 10.3389/fonc.2022.779939. PMID/PMCID: 35433481; PMC9009388.