A 3D-Bioprinted Decellularized Umbilical Cord Matrix Patch for Enhanced Storage and Deliveryof Extracellular Vesicles in Diabetic Wound Healing

Quick Facts

  • Publication title: A 3D-Bioprinted Decellularized Umbilical Cord Matrix Patch for Enhanced Storage and Deliveryof Extracellular Vesicles in Diabetic Wound Healing
  • Journal: Research
  • Year: 2026
  • DOI: 10.34133/research.1246
  • PMID/PMCID: 42027992; PMC13100348

Research overview

Herein, we developed a 3-dimensional bioprinted methacrylated decellularized umbilical cord matrix (MDUM) patch enabling the sustained delivery of telomerase-immortalized umbilical cord mesenchymal stem cell-derived EVs (TMSC-EVs). In a diabetic murine wound model, our data demonstrated that MDUM could enhance the retention and delivery of TMSC-EVs and further augment the therapeutic effects for diabetic wound healing as revealed by attenuating proinflammatory cytokine levels, enhancing neovascularization, and accelerating collagen deposition.

Key findings

Extracellular vesicles (EVs) are promising cell-free therapeutics for diabetic wound healing due to their immunomodulatory and proangiogenic properties.

Nonetheless, challenges in ensuring long-term stability and achieving targeted delivery continue to impede clinical translation.

Herein, we developed a 3-dimensional bioprinted methacrylated decellularized umbilical cord matrix (MDUM) patch enabling the sustained delivery of telomerase-immortalized umbilical cord mesenchymal stem cell-derived EVs (TMSC-EVs).

In a diabetic murine wound model, our data demonstrated that MDUM could enhance the retention and delivery of TMSC-EVs and further augment the therapeutic effects for diabetic wound healing as revealed by attenuating proinflammatory cytokine levels, enhancing neovascularization, and accelerating collagen deposition.

Echo Biotech Role

Echo Biotech contributed EV isolation and purification; the study also used or cited Exosupur®.

Related platforms: Exoomics®, Research Reagents & Tools

Related services and capabilities: EV Isolation & Purification, Research Reagent / Product Supply

Related products or reagents: Exosupur® EV Isolation/Purification Kit

References

Original publication: A 3D-Bioprinted Decellularized Umbilical Cord Matrix Patch for Enhanced Storage and Deliveryof Extracellular Vesicles in Diabetic Wound Healing Research. 2026. DOI: 10.34133/research.1246. PMID/PMCID: 42027992; PMC13100348.