Adipocyte-Derived Exosomal MTTP Suppresses Ferroptosis and Promotes Chemoresistance in Colorectal Cancer
Quick Facts
- Publication title: Adipocyte-Derived Exosomal MTTP Suppresses Ferroptosis and Promotes Chemoresistance in Colorectal Cancer
- Journal: Adv Sci
- Year: 2022
- DOI: 10.1002/advs.202203357
- PMID/PMCID: 35978266; PMC9534973
Research overview
Obesity is closely related to a poor prognosis in patients with advanced colorectal cancer (CRC), but the mechanisms remain unclear. The results reveal a novel intracellular signaling pathway mediated by adipose-derived exosomes and suggest that treatments targeting secreted MTTP might reverse oxaliplatin resistance in CRC.
Key findings
Obesity is closely related to a poor prognosis in patients with advanced colorectal cancer (CRC), but the mechanisms remain unclear.
Ferroptosis is a form of nonapoptotic cell death characterized by lipid reactive oxygen species (ROS) accumulation and iron dependency and is associated with the chemoresistance of tumors.
Here, it is shown that adipose-derived exosomes reduce ferroptosis susceptibility in CRC, thus promoting chemoresistance to oxaliplatin.
It is found that microsomal triglyceride transfer protein (MTTP) expression is increased in the plasma exosomes of CRC patients with a high body fat ratio, serving as an inhibitor of ferroptosis and reducing sensitivity to chemotherapy.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification, EV characterization.
Related platforms: Exoomics®
Related services and capabilities: Cell-Culture Supernatant EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB)
References
Original publication: Adipocyte-Derived Exosomal MTTP Suppresses Ferroptosis and Promotes Chemoresistance in Colorectal Cancer Advanced Science. 2022. DOI: 10.1002/advs.202203357. PMID/PMCID: 35978266; PMC9534973.