Autophagic extracellular vesicles (AEVs) are distinct from exosomes and play crucial roles in viral infections
Quick Facts
- Publication title: Autophagic extracellular vesicles (AEVs) are distinct from exosomes and play crucial roles in viral infections
- Journal: Nat Commun
- Year: 2025
- DOI: 10.1038/s41467-025-67860-9
- PMID/PMCID: 41423474; PMC12852855
Research overview
Emerging evidence indicates important interconnections between autophagy and the secretion of small extracellular vesicles. However, our understanding of these secretory vesicles remains incomplete.
Key findings
Emerging evidence indicates important interconnections between autophagy and the secretion of small extracellular vesicles.
However, our understanding of these secretory vesicles remains incomplete.
Here, we identify a subtype of small extracellular vesicles, termed autophagic extracellular vesicles (AEVs), which are distinct from exosomes.
Extracellular AEVs characterized by a size less than 100 nm exhibit increased secretion when the autophagy response is induced.
Echo Biotech Role
Echo Biotech contributed EV proteomics.
Related platforms: Exoomics®
Related services and capabilities: EV Proteomics
References
Original publication: Autophagic extracellular vesicles (AEVs) are distinct from exosomes and play crucial roles in viral infections Nature communications. 2025. DOI: 10.1038/s41467-025-67860-9. PMID/PMCID: 41423474; PMC12852855.