Bioinformatics analysis reveals the landscape of immune cell infiltration and novel immune-related biomarkers in moyamoya disease

Quick Facts

• Publication title: Bioinformatics analysis reveals the landscape of immune cell infiltration and novel immune-related biomarkers in moyamoya disease
• Journal: Front Genet
• Year: 2023
• DOI: 10.3389/fgene.2023.1101612
• PMID/PMCID: 37265961; PMC10230076

Research overview

Objective: This study aimed to identify immune infiltration characteristics and new immunological diagnostic biomarkers in the cerebrovascular tissue of moyamoya disease (MMD) using bioinformatics analysis. These immune-related genes and cells may provide novel insights for immunotherapy in the future.

Key findings

Objective: This study aimed to identify immune infiltration characteristics and new immunological diagnostic biomarkers in the cerebrovascular tissue of moyamoya disease (MMD) using bioinformatics analysis.

Methods: GSE189993 and GSE141022 were downloaded from the GEO database.

Differentially expressed gene and PPI analysis were performed.

After performing WGCNA, the most significant module associated with MMD was obtained.

Echo Biotech Role

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References

Original publication: Bioinformatics analysis reveals the landscape of immune cell infiltration and novel immune-related biomarkers in moyamoya disease Front Genet. 2023. DOI: 10.3389/fgene.2023.1101612. PMID/PMCID: 37265961; PMC10230076.