Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p

Quick Facts

• Publication title: Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p
• Journal: Commun Biol
• Year: 2022
• DOI: 10.1038/s42003-022-04263-2
• PMID/PMCID: 36476986; PMC9729231

Research overview

Here, we identified 222 differentially expressed circRNAs in SPEVs between boars with high or low sperm motility. Our results suggest that circ-CREBBP may be a promising biomarker and therapeutic target for male reproductive diseases.

Key findings

Male reproductive diseases are becoming increasingly prominent, and sperm quality is an important indicator to reflect these diseases.

Seminal plasma extracellular vesicles (SPEVs) are involved in sperm motility.

However, their effects on sperm remain unclear.

Here, we identified 222 differentially expressed circRNAs in SPEVs between boars with high or low sperm motility.

Echo Biotech Role

Echo Biotech contributed EV characterization, whole-transcriptome sequencing.

Related platforms: Exoomics®

Related services and capabilities: EV Basic Characterization (TEM/NTA/WB), EV Whole-Transcriptome Sequencing

References

Original publication: Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p Commun Biol. 2022. DOI: 10.1038/s42003-022-04263-2. PMID/PMCID: 36476986; PMC9729231.