CircBTBD7-420aa Encoded by hsa_circ_0000563 Regulates the Progression of Atherosclerosis and Construction of circBTBD7-420aa Engineered Exosomes
Quick Facts
- Publication title: CircBTBD7-420aa Encoded by hsa_circ_0000563 Regulates the Progression of Atherosclerosis and Construction of circBTBD7-420aa Engineered Exosomes
- Journal: JACC Basic Transl Sci
- Year: 2025
- DOI: 10.1016/j.jacbts.2024.09.003
- PMID/PMCID: 40131148; PMC11897471
Research overview
We found a new protein, circBTBD7-420aa, encoded by hsa_circ_0000563. This study suggests that circBTBD7-420aa may inhibit the progression of atherosclerosis and serve as a new target for the diagnosis and treatment of coronary artery disease.
Key findings
Circular RNAs are associated with cardiovascular disease, including coronary artery disease, but the mechanisms have not been completely elucidated.
We found a new protein, circBTBD7-420aa, encoded by hsa_circ_0000563.
Our results suggest that circBTBD7-420aa may inhibit the abnormal proliferation and migration of human coronary artery smooth muscle cells by promoting SLC3A2 degradation through the ubiquitin-proteasome pathway.
In addition, we constructed engineered exosomes loaded with circBTBD7-420aa that can target vascular smooth muscle cells by modifying peptide fragments targeting osteopontin.
Echo Biotech Role
Echo Biotech contributed cargo loading.
Related platforms: Echosome®
Related services and capabilities: Small RNA / Cargo Loading
References
Original publication: CircBTBD7-420aa Encoded by hsa_circ_0000563 Regulates the Progression of Atherosclerosis and Construction of circBTBD7-420aa Engineered Exosomes JACC-Basic to translational science. 2025. DOI: 10.1016/j.jacbts.2024.09.003. PMID/PMCID: 40131148; PMC11897471.