Circulating exosome-derived miR-122-5p is a novel biomarker for prediction of postoperative atrial fibrillation
Quick Facts
- Publication title: Circulating exosome-derived miR-122-5p is a novel biomarker for prediction of postoperative atrial fibrillation
- Journal: J CARDIOVASC TRANSL
- Year: 2022
- DOI: 10.1007/s12265-022-10267-4
- PMID/PMCID: 35513595
Research overview
Our study aimed to identify the difference in exosomal miRNA and further explore its role in the diagnosis of POAF. Our study revealed that exosomal miRNAs exert enormous potential in evaluating the severity or prognostic of POAF.
Key findings
Postoperative atrial fibrillation (POAF) is a frequent complication associated with increased periprocedural mortality and morbidity after cardiac surgery.
Our study aimed to identify the difference in exosomal miRNA and further explore its role in the diagnosis of POAF.
First, the differentially expressed miRNAs (DEMs) were obtained by high-throughput RNA sequencing.
Second, the DEMs target genes were put into gene ontology (GO) and KEGG pathway analysis.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification; the study also used or cited Exosupur®.
Related platforms: Exoomics®, Research Reagents & Tools
Related services and capabilities: EV Isolation & Purification, Research Reagent / Product Supply
Related products or reagents: Exosupur® EV Isolation/Purification Kit
References
Original publication: Circulating exosome-derived miR-122-5p is a novel biomarker for prediction of postoperative atrial fibrillation Journal of Cardiovascular Translational Research. 2022. DOI: 10.1007/s12265-022-10267-4. PMID/PMCID: 35513595.