Dynamic immune and exosome transcriptomic responses in patients undergoing psychostimulant methamphetamine withdrawal
Quick Facts
- Publication title: Dynamic immune and exosome transcriptomic responses in patients undergoing psychostimulant methamphetamine withdrawal
- Journal: Front Cell Neurosci
- Year: 2022
- DOI: 10.3389/fncel.2022.961131
- PMID/PMCID: 36238831; PMC9550894
Research overview
Herein, we investigated the peripheral cytokines and exosomal transcriptome regulatory networks in the patients with METH use disorders (MUDs) undergoing withdrawal. However, the pathogenesis remains largely unknown.
Key findings
Methamphetamine (METH) addiction and withdrawal cause serious harm to both the immune system and nervous system.
However, the pathogenesis remains largely unknown.
Herein, we investigated the peripheral cytokines and exosomal transcriptome regulatory networks in the patients with METH use disorders (MUDs) undergoing withdrawal.
Twenty-seven cytokines were simultaneously assessed in 51 subjects, including 22 at the acute withdrawal (AW) stage and 29 at the protracted withdrawal (PW) stage, and 31 age and gender-matched healthy controls (HCs).
Echo Biotech Role
Echo Biotech contributed EV isolation and purification, lncRNA/mRNA sequencing, whole-transcriptome sequencing; the study also used or cited Exosupur®.
Related platforms: Exoomics®, Research Reagents & Tools
Related services and capabilities: Biofluid EV Isolation & Purification, EV lncRNA/mRNA Sequencing, EV Whole-Transcriptome Sequencing, Research Reagent / Product Supply
Related products or reagents: Exosupur® EV Isolation/Purification Kit
References
Original publication: Dynamic immune and exosome transcriptomic responses in patients undergoing psychostimulant methamphetamine withdrawal Front Cell Neurosci. 2022. DOI: 10.3389/fncel.2022.961131. PMID/PMCID: 36238831; PMC9550894.