Enhancement of acellular cartilage matrix scaffold by Wharton's jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration
Quick Facts
- Publication title: Enhancement of acellular cartilage matrix scaffold by Wharton's jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration
- Journal: Bioact Mater
- Year: 2021
- DOI: 10.1016/j.bioactmat.2021.01.031
- PMID/PMCID: 33665503; PMC7895679
Research overview
The purpose of this study was to verify whether MSC-Exos can enhance the reparative effect of the acellular cartilage extracellular matrix (ACECM) scaffold and to explore the underlying mechanism. This effect was mainly manifested in promoting the polarization of macrophages toward the M2 phenotype and inhibiting the inflammatory response, which may be a promoting factor for osteochondral regeneration.
Key findings
Articular cartilage defect repair is a problem that has long plagued clinicians.
Although mesenchymal stem cells (MSCs) have the potential to regenerate articular cartilage, they also have many limitations.
Recent studies have found that MSC-derived exosomes (MSC-Exos) play an important role in tissue regeneration.
The purpose of this study was to verify whether MSC-Exos can enhance the reparative effect of the acellular cartilage extracellular matrix (ACECM) scaffold and to explore the underlying mechanism.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification, EV characterization, miRNA profiling/sequencing and bioinformatic analysis.
Related platforms: Exoomics®
Related services and capabilities: EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing
References
Original publication: Enhancement of acellular cartilage matrix scaffold by Wharton's jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration Bioact Mater. 2021. DOI: 10.1016/j.bioactmat.2021.01.031. PMID/PMCID: 33665503; PMC7895679.