Exosomal PD-L1 and N-cadherin predict pulmonary metastasis progression for osteosarcoma patients
Quick Facts
- Publication title: Exosomal PD-L1 and N-cadherin predict pulmonary metastasis progression for osteosarcoma patients
- Journal: J Nanobiotechnol
- Year: 2020
- DOI: 10.1186/s12951-020-00710-6
- PMID/PMCID: 33092576; PMC7579953
Research overview
We examined serum exosomes from 70 OS patients, 9 patients with benign tumors and 22 healthy donors. Detection of exosomal PD-L1 and N-cadherin from serum of OS patients may predict pulmonary metastasis progression for OS patients.
Key findings
The characteristics of exosomes derived from OS patient serum and OS cell lines were confirmed by several methods.
We found OS patients had a higher level of exosomal PD-L1 compared to healthy donors.
Meanwhile, OS patients with pulmonary metastasis also showed a relatively higher level of exosomal PD-L1 than patients without metastasis.
Next, bioinformatic analysis demonstrated that Sr-exosomes isolated from OS patients may involve in the important process of immune function and cancer pathogenesis for OS patients.
Echo Biotech Role
Echo Biotech contributed lncRNA/mRNA sequencing.
Related platforms: Exoomics®
Related services and capabilities: EV lncRNA/mRNA Sequencing
References
Original publication: Exosomal PD-L1 and N-cadherin predict pulmonary metastasis progression for osteosarcoma patients J Nanobiotechnol. 2020. DOI: 10.1186/s12951-020-00710-6. PMID/PMCID: 33092576; PMC7579953.