Exosomes derived from oral squamous cell carcinoma tissue accelerate diabetic wound healing
Quick Facts
- Publication title: Exosomes derived from oral squamous cell carcinoma tissue accelerate diabetic wound healing
- Journal: AM J PHYSIOL-CELL PH
- Year: 2023
- DOI: 10.1152/ajpcell.00541.2022
- PMID/PMCID: 37154491
Research overview
In this study, we extracted Ti-Exos from human oral squamous carcinoma and paracancerous tissue by ultracentrifugation, size exclusion chromatography, and ultrafiltration and performed exosome characterization. In vivo assays also verified that OSCC Ti-Exos could promote diabetic wound healing, demonstrated preliminary biosafety in mice, and have promise as therapeutic applications.
Key findings
It is a widespread and difficult problem that refractory diabetic wounds have a poor local environment and prolonged inflammatory irritation.
Tumor cell-derived exosomes play an important role in the development of tumors, as they can promote tumor cell proliferation, migration, and invasion and enhance tumor cell activity.
However, tumor tissue-derived exosomes (Ti-Exos) have been less studied, and it is unclear how they affect wound healing.
In this study, we extracted Ti-Exos from human oral squamous carcinoma and paracancerous tissue by ultracentrifugation, size exclusion chromatography, and ultrafiltration and performed exosome characterization.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification, EV characterization.
Related platforms: Exoomics®
Related services and capabilities: Tissue EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB)
References
Original publication: Exosomes derived from oral squamous cell carcinoma tissue accelerate diabetic wound healing AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2023. DOI: 10.1152/ajpcell.00541.2022. PMID/PMCID: 37154491.