Extracellular vesicle microRNA cargoes from intermittent hypoxiaexposed cardiomyocytes and their effect on endothelium
Quick Facts
- Publication title: Extracellular vesicle microRNA cargoes from intermittent hypoxiaexposed cardiomyocytes and their effect on endothelium
- Journal: Biochem Bioph Res Co
- Year: 2021
- DOI: 10.1016/j.bbrc.2021.02.034
- PMID/PMCID: 33647794
Research overview
In current study, we attempt to compare the disparity of myocardial EV miRNA components after IH or normoxia treatment and determine whether EVs from IH-treated cardiomyocytes could affect endothelial function. However, the mechanism has not been fully elucidated.
Key findings
Intermittent hypoxia (IH), a main characteristic of obstructive sleep apnea (OSA) syndrome, is an independent risk factor of cardiovascular complications.
However, the mechanism has not been fully elucidated.
Growing evidence has revealed alterations of extracellular vesicle (EV) contents, mostly miRNAs, playing a pathogenic role in cardiovascular complications.
In current study, we attempt to compare the disparity of myocardial EV miRNA components after IH or normoxia treatment and determine whether EVs from IH-treated cardiomyocytes could affect endothelial function.
Echo Biotech Role
Echo Biotech contributed miRNA profiling/sequencing and bioinformatic analysis.
Related platforms: Exoomics®
Related services and capabilities: EV miRNA Profiling / Sequencing
References
Original publication: Extracellular vesicle microRNA cargoes from intermittent hypoxiaexposed cardiomyocytes and their effect on endothelium Biochem Bioph Res Co. 2021. DOI: 10.1016/j.bbrc.2021.02.034. PMID/PMCID: 33647794.