Extracellular vesicles produced by avian pathogenic Escherichia coli (APEC) activate macrophage proinflammatory response and neutrophil extracellular trap (NET) formation through TLR4 signaling
Quick Facts
- Publication title: Extracellular vesicles produced by avian pathogenic Escherichia coli (APEC) activate macrophage proinflammatory response and neutrophil extracellular trap (NET) formation through TLR4 signaling
- Journal: Microb Cell Fact
- Year: 2023
- DOI: 10.1186/s12934-023-02171-6
- PMID/PMCID: 37689682; PMC10492386
Research overview
In this study, we investigated the relationships between APEC EVs and immune cells. APEC extracellular vesicles (EVs) may play vital roles in the interaction of the pathogen with its host cells.
Key findings
In this study, we investigated the relationships between APEC EVs and immune cells.
The production and characteristics of the EVs of APEC isolate CT265 were identified.
Toll like receptor 4 (TLR4) triggered the cellular immune responses when it interacted with APEC EVs.
APEC EVs induced a significant release of proinflammatory cytokines in THP-1 macrophages.
Echo Biotech Role
Echo Biotech contributed EV characterization.
Related platforms: Exoomics®
Related services and capabilities: EV Basic Characterization (TEM/NTA/WB)
References
Original publication: Extracellular vesicles produced by avian pathogenic Escherichia coli (APEC) activate macrophage proinflammatory response and neutrophil extracellular trap (NET) formation through TLR4 signaling Microb Cell Fact. 2023. DOI: 10.1186/s12934-023-02171-6. PMID/PMCID: 37689682; PMC10492386.