Induced Mammary Epithelial Cell-Derived Extracellular Vesicles Promote the Repair of Skin Trauma
Quick Facts
- Publication title: Induced Mammary Epithelial Cell-Derived Extracellular Vesicles Promote the Repair of Skin Trauma
- Journal: Int J Mol Sci
- Year: 2025
- DOI: 10.3390/ijms26209929
- PMID/PMCID: 41155223; PMC12564146
Research overview
This study is the first to demonstrate that extracellular vesicles from chemically induced mammary epithelial cells (CiMECs-EVs) possess distinct skin wound repair activity. This system is expected to provide an effective and innovative EV-based therapeutic strategy for the clinical treatment of skin wound repair.
Key findings
Although extracellular vesicles (EVs) from mesenchymal stem cells have shown potential in skin wound repair, the diversity of EV sources and the optimization of delivery systems still need further exploration.
This study is the first to demonstrate that extracellular vesicles from chemically induced mammary epithelial cells (CiMECs-EVs) possess distinct skin wound repair activity.
To enhance the therapeutic efficacy of CiMECs-EVs and optimize their delivery efficiency, we innovatively combined them with a chitosan hydrogel to construct a composite repair system (CiMECs-EVs-chitosan hydrogel, CMECG).
This system was then applied to a rat skin wound model.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification, miRNA profiling/sequencing and bioinformatic analysis.
Related platforms: Exoomics®
Related services and capabilities: EV Isolation & Purification, EV miRNA Profiling / Sequencing
References
Original publication: Induced Mammary Epithelial Cell-Derived Extracellular Vesicles Promote the Repair of Skin Trauma International journal of molecular sciences. 2025. DOI: 10.3390/ijms26209929. PMID/PMCID: 41155223; PMC12564146.