Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc-MKRN2-42:1 in the pathogenesis of Parkinson's disease
Quick Facts
- Publication title: Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc-MKRN2-42:1 in the pathogenesis of Parkinson's disease
- Journal: CNS Neurosci Ther
- Year: 2020
- DOI: 10.1111/cns.13277
- PMID/PMCID: 31814304; PMC7163584
Research overview
To study expression differences for lncRNAs in peripheral blood exosomes of PD patients compared with healthy individuals and to look for lncRNAs that might be related to the pathogenesis of PD. Our study suggested that lnc-MKRN2-42:1 may be involved in the occurrence and development of PD.
Key findings
We found 15 upregulated and 24 downregulated exosomal lncRNAs in the PD group.
According to bioinformatics analyses, we chose lnc-MKRN2-42:1 for further study.
Interestingly, lnc-MKRN2-42:1 was positively correlated with the MDS-UPDRS III score for PD patients.
Study design
We recruited PD patients along with age- and sex-matched healthy individuals as healthy controls and evaluated levels of lncRNAs extracted from exosomes in plasma samples via next-generation sequencing and real-time quantitative PCR.
Correlation analysis was conducted for the clinical characteristics of PD patients and the expression of selected lncRNAs.
Echo Biotech Role
Echo Biotech contributed lncRNA/mRNA sequencing.
Related platforms: Exoomics®
Related services and capabilities: EV lncRNA/mRNA Sequencing
References
Original publication: Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc-MKRN2-42:1 in the pathogenesis of Parkinson's disease CNS Neurosci Ther. 2020. DOI: 10.1111/cns.13277. PMID/PMCID: 31814304; PMC7163584.