LncHLEF promotes hepatic lipid synthesis through miR-2188-3p/GATA6 axis and encoding peptides and enhances intramuscular fat deposition via exosome
Quick Facts
- Publication title: LncHLEF promotes hepatic lipid synthesis through miR-2188-3p/GATA6 axis and encoding peptides and enhances intramuscular fat deposition via exosome
- Journal: Int J Biol Macromol
- Year: 2023
- DOI: 10.1016/j.ijbiomac.2023.127061
- PMID/PMCID: 37751822
Research overview
In conclusion, this study revealed that the lncHLEF could promote hepatic lipid synthesis through two independent regulatory mechanisms, and could enhance IMF deposition via hepatocyte-adipocyte communications mediated by exosome. However, their biological functions and regulatory mechanisms underlying adipogenesis remain largely elusive in chicken.
Key findings
Long noncoding RNAs (lncRNAs) have emergingly been implicated in mammalian lipid metabolism.
However, their biological functions and regulatory mechanisms underlying adipogenesis remain largely elusive in chicken.
Here, we systematically characterized the genome-wide full-length lncRNAs in the livers of pre- and peak-laying hens, and identified a novel intergenic lncRNA, lncHLEF, an RNA macromolecule with a calculated molecular weight of 433 kDa.
lncHLEF was primarily distributed in cytoplasm of chicken hepatocyte and significantly up-regulated in livers of peak-laying hens.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification; the study also used or cited Exosupur®.
Related platforms: Exoomics®, Research Reagents & Tools
Related services and capabilities: EV Isolation & Purification, Research Reagent / Product Supply
Related products or reagents: Exosupur® EV Isolation/Purification Kit
References
Original publication: LncHLEF promotes hepatic lipid synthesis through miR-2188-3p/GATA6 axis and encoding peptides and enhances intramuscular fat deposition via exosome Int J Biol Macromol. 2023. DOI: 10.1016/j.ijbiomac.2023.127061. PMID/PMCID: 37751822.