lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke

Quick Facts

  • Publication title: lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke
  • Journal: Sci Data
  • Year: 2025
  • DOI: 10.1038/s41597-025-04410-4
  • PMID/PMCID: 39820519; PMC11739660

Research overview

This dataset provides a significant resource for relevant researchers to explore the potential dysregulated lncRNAs, miRNAs, and mRNAs of plasma and tumour-derived exosomes in CM-IS. Tumour-derived exosomes play a crucial role in tumour growth, metastasis, immune regulation, and monitor disease development.

Key findings

Cardiac myxoma (CM) is an important aetiology of stroke in young adults, and its diagnosis is difficult in patients having stroke because of the lack of diagnostic biomarkers.

Tumour-derived exosomes play a crucial role in tumour growth, metastasis, immune regulation, and monitor disease development.

Hence,we established an RNA-sequencing dataset for long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) in the plasma and tumour-derived exosomes from four patients with cardiac myxoma-related ischaemic stroke (CM-IS) and six patients with cardiac myxoma without ischaemic stroke (non-IS CM).

Moreover, 5,533 lncRNAs, 1,331 known miRNAs, and 412 new miRNAs were identified.

Echo Biotech Role

Echo Biotech contributed EV isolation and purification, EV characterization, whole-transcriptome sequencing; the study also used or cited Exosupur®.

Related platforms: Exoomics®, Research Reagents & Tools

Related services and capabilities: Biofluid EV Isolation & Purification, Tissue EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV Whole-Transcriptome Sequencing, Research Reagent / Product Supply

Related products or reagents: Exosupur® EV Isolation/Purification Kit

References

Original publication: lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke Scientific Data. 2025. DOI: 10.1038/s41597-025-04410-4. PMID/PMCID: 39820519; PMC11739660.