Long non-coding RNA and circular RNA and coding RNA profiling of plasma exosomes of osteosarcoma by RNA seq
Quick Facts
- Publication title: Long non-coding RNA and circular RNA and coding RNA profiling of plasma exosomes of osteosarcoma by RNA seq
- Journal: Sci Data
- Year: 2023
- DOI: 10.1038/s41597-023-02295-9
- PMID/PMCID: 37349312; PMC10287625
Research overview
Osteosarcoma (OS) is a primary bone tumor with high malignancy and the mechanism of hematogenous metastasis in OS is still not clear. This data set provides a significant resource for relevant researchers to excavate potential dysregulated lncRNAs, circRNAs and mRNAs of plasma exosomes in OS versus normal conditions.
Key findings
Osteosarcoma (OS) is a primary bone tumor with high malignancy and the mechanism of hematogenous metastasis in OS is still not clear.
The plasma exosomes derived from osteosarcoma play a key role in the process of tumor metastasis.
Here, we established RNA-seq dataset for lncRNAs, circRNAs and mRNAs in plasma exosomes from 10 OS patients and 5 healthy donors.
52 Gb of clean data was obtained.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification, EV characterization, lncRNA/mRNA sequencing.
Related platforms: Exoomics®
Related services and capabilities: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV lncRNA/mRNA Sequencing
References
Original publication: Long non-coding RNA and circular RNA and coding RNA profiling of plasma exosomes of osteosarcoma by RNA seq Sci Data. 2023. DOI: 10.1038/s41597-023-02295-9. PMID/PMCID: 37349312; PMC10287625.