Malignant ascites-derived exosomes promote peritoneal tumor cell dissemination and reveal a distinct miRNA signature in advanced gastric cancer
Quick Facts
- Publication title: Malignant ascites-derived exosomes promote peritoneal tumor cell dissemination and reveal a distinct miRNA signature in advanced gastric cancer
- Journal: Cancer Lett
- Year: 2019
- DOI: 10.1016/j.canlet.2019.04.034
- PMID/PMCID: 31075288
Research overview
Thus, this study aims to investigate the effects of malignant ascites (MA)-derived exosomes from GC patients on tumor cells and to elucidate the underlying mechanism. However, the molecular mechanisms of PD remain poorly defined.
Key findings
Peritoneal dissemination (PD) is the most frequent metastasis with poor prognosis in patients with advanced gastric cancer (GC).
However, the molecular mechanisms of PD remain poorly defined.
Exosomes play a pivotal role in cancer progression.
Thus, this study aims to investigate the effects of malignant ascites (MA)-derived exosomes from GC patients on tumor cells and to elucidate the underlying mechanism.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification, EV characterization, miRNA profiling/sequencing and bioinformatic analysis.
Related platforms: Exoomics®
Related services and capabilities: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing
References
Original publication: Malignant ascites-derived exosomes promote peritoneal tumor cell dissemination and reveal a distinct miRNA signature in advanced gastric cancer Cancer Lett. 2019. DOI: 10.1016/j.canlet.2019.04.034. PMID/PMCID: 31075288.