MicroRNA-222 Transferred From Semen Extracellular Vesicles Inhibits Sperm Apoptosis by Targeting BCL2L11
Quick Facts
- Publication title: MicroRNA-222 Transferred From Semen Extracellular Vesicles Inhibits Sperm Apoptosis by Targeting BCL2L11
- Journal: Front Cell Dev Biol
- Year: 2021
- DOI: 10.3389/fcell.2021.736864
- PMID/PMCID: 34820370; PMC8607813
Research overview
The study of the whole transcriptomes and proteomes of EVs in boar semen revealed some miRNAs may play an important role in these EVs interactions with Duroc sperm, and the findings suggest that the release of miR-222 by semen EVs is an important mechanism by which sperm viability is maintained and sperm apoptosis is reduced. Our studies provide a new insight of miR-222 in EVs regulation for sperm motility and sperm apoptosis.
Key findings
Seminal plasma contains a large number of extracellular vesicles (EVs).
However, the roles of these EVs and their interactions with sperm are not clear.
To identify the important molecules affecting sperm motility in EVs, we analyzed RNA from seminal plasma EVs of boars with different sperm motility using whole-transcriptome sequencing and proteomic analysis.
In total, 7 miRNAs, 67 lncRNAs, 126 mRNAs and 76 proteins were differentially expressed between the two groups.
Echo Biotech Role
Echo Biotech contributed EV characterization, whole-transcriptome sequencing.
Related platforms: Exoomics®
Related services and capabilities: EV Basic Characterization (TEM/NTA/WB), EV Whole-Transcriptome Sequencing
References
Original publication: MicroRNA-222 Transferred From Semen Extracellular Vesicles Inhibits Sperm Apoptosis by Targeting BCL2L11 Front Cell Dev Biol. 2021. DOI: 10.3389/fcell.2021.736864. PMID/PMCID: 34820370; PMC8607813.