MicroRNA-6084 orchestrates angiogenesis and liver metastasis in colorectal cancer via extracellular vesicles
Quick Facts
- Publication title: MicroRNA-6084 orchestrates angiogenesis and liver metastasis in colorectal cancer via extracellular vesicles
- Journal: JCI Insight
- Year: 2025
- DOI: 10.1172/jci.insight.189503
- PMID/PMCID: 40493409; PMC12288965
Research overview
Our study demonstrates that H-EVs induce angiogenesis and liver metastasis. In summary, our findings suggest that CRC-derived H-EVs promote angiogenesis and liver metastasis through the HIF1A/SP1/miR-6084/ANGPTL4 axis.
Key findings
The prognosis for colorectal cancer (CRC) patients with liver metastasis remains poor, and the molecular mechanisms driving CRC liver metastasis are not fully understood.
Tumor-derived hypoxia-induced extracellular vesicles have emerged as key players in inducing angiogenesis by transferring noncoding RNAs.
However, the specific role of CRC-derived hypoxic extracellular vesicles (H-EVs) in regulating premetastatic microenvironment (PMN) formation by inducing angiogenesis remains unclear.
Our study demonstrates that H-EVs induce angiogenesis and liver metastasis.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification, miRNA profiling/sequencing and bioinformatic analysis; the study also used or cited Exosupur®.
Related platforms: Exoomics®, Research Reagents & Tools
Related services and capabilities: Biofluid EV Isolation & Purification, Cell-Culture Supernatant EV Isolation & Purification, EV miRNA Profiling / Sequencing, Research Reagent / Product Supply
Related products or reagents: Exosupur® EV Isolation/Purification Kit
References
Original publication: MicroRNA-6084 orchestrates angiogenesis and liver metastasis in colorectal cancer via extracellular vesicles JCI Insight. 2025. DOI: 10.1172/jci.insight.189503. PMID/PMCID: 40493409; PMC12288965.