miRNA Profiling of Cholesteatoma-Derived Exosomes Reveals Exosomal miR-223-3p and miR-142-5p as Potential Biomarkers for Acquired Middle Ear Cholesteatoma

Quick Facts

• Publication title: miRNA Profiling of Cholesteatoma-Derived Exosomes Reveals Exosomal miR-223-3p and miR-142-5p as Potential Biomarkers for Acquired Middle Ear Cholesteatoma
• Journal: World J Otorhinolaryngol Head Neck Surg
• Year: 2025
• DOI: 10.1002/wjo2.70057

Research overview

We found 14 upregulated miRNAs and 25 downregulated miRNAs in the cholesteatoma‐derived exosomes. The potential roles of differentially expressed miRNAs (DE‐miRNAs) were investigated using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses.

Echo Biotech Role

Echo Biotech contributed EV isolation and purification, EV characterization, qPCR validation; the study also used or cited Exosupur®.

Related platforms: Exoomics®, Research Reagents & Tools

Related services and capabilities: Biofluid EV Isolation & Purification, Tissue EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), qPCR Validation, Research Reagent / Product Supply

Related products or reagents: Exosupur® EV Isolation/Purification Kit

References

Original publication: miRNA Profiling of Cholesteatoma-Derived Exosomes Reveals Exosomal miR-223-3p and miR-142-5p as Potential Biomarkers for Acquired Middle Ear Cholesteatoma World Journal of Otorhinolaryngology-Head & Neck Surgery. 2025. DOI: 10.1002/wjo2.70057.