Mitochondrial translocation of immunostimulatory RNA RN7SL1 suppresses innate immune responses
Quick Facts
- Publication title: Mitochondrial translocation of immunostimulatory RNA RN7SL1 suppresses innate immune responses
- Journal: Acta Biochim Biophys Sin (Shanghai)
- Year: 2026
- DOI: 10.3724/abbs.2026079
- PMID/PMCID: 42178286
Research overview
In this study, we demonstrate that the nuclear-encoded immunostimulatory RNA RN7SL1 could be translocated into the mitochondria from the cytosol. These findings reveal a novel mitochondrial function in suppressing the immune response induced by immunostimulatory RNA.
Key findings
The significance of mitochondria in innate immunity is increasingly recognized.
Mitochondrial immunostimulatory nucleic acids released into the cytosol can trigger an innate immune response.
However, the possibility of translocating immunostimulatory nucleic acids from the cytosol to the mitochondria remains unexplored.
In this study, we demonstrate that the nuclear-encoded immunostimulatory RNA RN7SL1 could be translocated into the mitochondria from the cytosol.
Echo Biotech Role
Echo Biotech contributed specialized RNA-sequencing analysis.
Related platforms: Exoomics®
Related services and capabilities: Specialized RNA Sequencing
References
Original publication: Mitochondrial translocation of immunostimulatory RNA RN7SL1 suppresses innate immune responses Acta biochimica et biophysica Sinica. 2026. DOI: 10.3724/abbs.2026079. PMID/PMCID: 42178286.