A New Method Regulates Bone Fracture Tissue Exosome lncRNA-mRNA to Promote Mesenchymal Stem Cell Proliferation and Migration
Quick Facts
- Publication title: A New Method Regulates Bone Fracture Tissue Exosome lncRNA-mRNA to Promote Mesenchymal Stem Cell Proliferation and Migration
- Journal: Injury
- Year: 2023
- DOI: 10.1016/j.injury.2023.111210
- PMID/PMCID: 38006783
Research overview
This study was to discuss the role of fracture site tissue exosomes lncRNAs-mRNAs networks on PIA promoting bone mesenchymal stem cells (BMSCs) proliferation and migration. This study was to discuss the role of fracture site tissue exosomes lncRNAs-mRNAs networks on PIA promoting bone mesenchymal stem cells (BMSCs) proliferation and migration.
Key findings
Post-injury adaptation (PIA) is a simple and convenient method to promote bone healing, but its mechanism is unclear.
This study was to discuss the role of fracture site tissue exosomes lncRNAs-mRNAs networks on PIA promoting bone mesenchymal stem cells (BMSCs) proliferation and migration.
Firstly, the effects of PIA accelerating BMSCs proliferation and migration were confirmed by rat fracture model and bone fracture environment in vitro.
Besides, the fracture site tissue exosomes were isolated and authenticated.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification, lncRNA/mRNA sequencing.
Related platforms: Exoomics®
Related services and capabilities: Tissue EV Isolation & Purification, EV lncRNA/mRNA Sequencing
References
Original publication: A New Method Regulates Bone Fracture Tissue Exosome lncRNA-mRNA to Promote Mesenchymal Stem Cell Proliferation and Migration Injury. 2023. DOI: 10.1016/j.injury.2023.111210. PMID/PMCID: 38006783.