NIR-II Engineered Exosome Nanotheranostic Probes for "Oriented Blasting" in Orthotopic Glioblastoma

Quick Facts

  • Publication title: NIR-II Engineered Exosome Nanotheranostic Probes for "Oriented Blasting" in Orthotopic Glioblastoma
  • Journal: ACS Nano
  • Year: 2025
  • DOI: 10.1021/acsnano.5c01541
  • PMID/PMCID: 40539986

Research overview

This study offers an effective approach to glioblastoma therapy by integrating precision-targeted delivery, multimodal imaging, and synergistic therapeutic effects. The findings provide a theranostics platform aimed at overcoming current treatment limitations and improving clinical outcomes for cancer.

Key findings

Glioblastoma (GBM), a highly aggressive and lethal brain tumor, presents a formidable clinical challenge due to its poor prognosis and lack of effective treatment options, underscoring the urgent need for innovative therapeutic strategies.

Here, we report a promising phototheranostic platform based on a near-infrared II (NIR-II) organic molecule, MYM, which combines robust fluorescence with potent photothermal and photodynamic therapeutic capabilities.

To maximize efficacy, MYM was encapsulated in exosomes derived from 293F cells and further functionalized with the iRGD peptide, enhancing both tumor targeting and penetration of the blood-brain barrier (MYM@iRGD-Exo).

In vivo, studies demonstrate that MYM@iRGD-Exo can effectively penetrate the blood-brain barrier and selectively target GBM cells.

Echo Biotech Role

Echo Biotech contributed targeting-peptide/surface modification, EV material/reference-material supply; the study also used or cited ExoBrooch™, ContrExo®.

Related platforms: Echosome®, EV Materials / Reference Materials, Research Reagents & Tools

Related services and capabilities: Targeting Peptide / Surface Modification, EV Material / Reference Material Supply

Related products or reagents: ExoBrooch™ Targeting Peptide/Lipid Anchor Kit, ContrExo® EV Reference Material

References

Original publication: NIR-II Engineered Exosome Nanotheranostic Probes for "Oriented Blasting" in Orthotopic Glioblastoma ACS Nano. 2025. DOI: 10.1021/acsnano.5c01541. PMID/PMCID: 40539986.