NSCLC extracellular vesicles containing miR-374a-5p promote leptomeningeal metastasis by influencing blood‒brain barrier permeability
Quick Facts
- Publication title: NSCLC extracellular vesicles containing miR-374a-5p promote leptomeningeal metastasis by influencing blood‒brain barrier permeability
- Journal: Mol Cancer Res
- Year: 2024
- DOI: 10.1158/1541-7786.MCR-24-0052
- PMID/PMCID: 38639925; PMC11294816
Research overview
The purpose of this study was to examine the clinical value and role of EV miRNAs in NSCLC-LM. Implications: These results suggest that serum NSCLC-derived EV miR-374a-5p is involved in premetastatic niche formation by regulating the permeability of the blood-brain barrier to promote NSCLC-LM and can be used as a blood biomarker for the diagnosis and prognosis of NSCLC-LM.
Key findings
Leptomeningeal metastasis (LM) is a devastating complication of advanced non-small cell lung cancer (NSCLC).
Its diagnosis and monitoring can be challenging.
Recently, extracellular vesicle (EV) miRNAs have become a new noninvasive diagnostic biomarker.
The purpose of this study was to examine the clinical value and role of EV miRNAs in NSCLC-LM.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification, EV characterization, miRNA profiling/sequencing and bioinformatic analysis; the study also used or cited Exosupur®.
Related platforms: Exoomics®, Research Reagents & Tools
Related services and capabilities: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing, Research Reagent / Product Supply
Related products or reagents: Exosupur® EV Isolation/Purification Kit
References
Original publication: NSCLC extracellular vesicles containing miR-374a-5p promote leptomeningeal metastasis by influencing blood‒brain barrier permeability Mol Cancer Res. 2024. DOI: 10.1158/1541-7786.MCR-24-0052. PMID/PMCID: 38639925; PMC11294816.