An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery

Quick Facts

  • Publication title: An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery
  • Journal: Cell
  • Year: 2026
  • DOI: 10.1016/j.cell.2025.12.021
  • PMID/PMCID: 41605209

Research overview

Efficient and precise delivery of therapeutics toward target loci of organs is crucial for effective disease therapy. However, conventional devices face remarkable challenges to achieve clinically desirable conformality, spatial controllability, and efficiency, especially to organs with complex anatomies, due to a lack of appropriate mechanical and/or material properties.

Key findings

Efficient and precise delivery of therapeutics toward target loci of organs is crucial for effective disease therapy.

However, conventional devices face remarkable challenges to achieve clinically desirable conformality, spatial controllability, and efficiency, especially to organs with complex anatomies, due to a lack of appropriate mechanical and/or material properties.

Here, we report a bioelectronic patch for organ-conformal, kirigami-structured electro-transfection (POCKET) that features high conformality enabled by parametric customization, achieving a theoretically maximum effective coverage area over the target organ.

The four-layered POCKET forms a unique nanopore-cell juxtaposition configuration at the tissue-device interface, which induces precise, uniform electro-perforation while expediting intracellular transport of payloads.

Echo Biotech Role

Echo Biotech contributed EV isolation and purification; the study also used or cited Exosupur®.

Related platforms: Exoomics®, Research Reagents & Tools

Related services and capabilities: Tissue EV Isolation & Purification, Research Reagent / Product Supply

Related products or reagents: Exosupur® EV Isolation/Purification Kit

References

Original publication: An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery Cell. 2026. DOI: 10.1016/j.cell.2025.12.021. PMID/PMCID: 41605209.