Pericytes promote metastasis by regulating tumor local vascular tone and hemodynamics
Quick Facts
- Publication title: Pericytes promote metastasis by regulating tumor local vascular tone and hemodynamics
- Journal: Nat Commun
- Year: 2025
- DOI: 10.1038/s41467-025-62475-6
- PMID/PMCID: 40753165; PMC12318036
Research overview
Hemodynamics are important for survival and extravasation of circulating tumor cells, whereas the effects of hemodynamics on tumor cell intravasation remain mostly unknown. These findings reveal that TPCs-regulated vasodilation and hemodynamics facilitate tumor metastasis, and provide a potential prognostic marker and therapeutic strategy for tumor metastasis.
Key findings
Hemodynamics are important for survival and extravasation of circulating tumor cells, whereas the effects of hemodynamics on tumor cell intravasation remain mostly unknown.
Here, we show that colorectal cancer patients with liver metastasis are characterized by increased diameter and blood flow in the primary tumor compared with non-metastatic patients.
A subpopulation of NKX2-3high tumor pericytes (TPCs) in the primary tumor is associated with hematogenous metastasis of patients.
Mechanistically, long noncoding RNA NEAT1-enriched extracellular vesicles induce NKX2-3 upregulation in TPCs.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification; the study also used or cited Exosupur®.
Related platforms: Exoomics®, Research Reagents & Tools
Related services and capabilities: Biofluid EV Isolation & Purification, Research Reagent / Product Supply
Related products or reagents: Exosupur® EV Isolation/Purification Kit
References
Original publication: Pericytes promote metastasis by regulating tumor local vascular tone and hemodynamics Nature communications. 2025. DOI: 10.1038/s41467-025-62475-6. PMID/PMCID: 40753165; PMC12318036.