Placental trophoblast cells-derived exosomal microRNA-1290 promotes the interaction between endometrium and embryo by targeting LHX6
Quick Facts
- Publication title: Placental trophoblast cells-derived exosomal microRNA-1290 promotes the interaction between endometrium and embryo by targeting LHX6
- Journal: Mol Ther Nucl Acids
- Year: 2021
- DOI: 10.1016/j.omtn.2021.09.009
- PMID/PMCID: 34729246; PMC8526418
Research overview
Subsequently, we evaluated the loading miRNA in exosomes by small RNA sequencing. Altogether, our findings provide novel insights into the mechanism of trophoblast cell-derived exosomes during embryo implantation.
Key findings
Communication between the maternal uterus and the embryo is vital for a successful pregnancy.
Exosomes, subtypes of extracellular vesicles comprising many bioactive factors, regulate the early stages of pregnancy, specifically during embryo implantation.
Nevertheless, the mechanism by which exosomal microRNAs (miRNAs) derived from placental trophoblasts regulate embryo implantation remains elusive.
We isolated and identified exosomes derived from placental trophoblast cells (HTR8/SVneo).
Echo Biotech Role
Echo Biotech contributed miRNA profiling/sequencing and bioinformatic analysis.
Related platforms: Exoomics®
Related services and capabilities: EV miRNA Profiling / Sequencing
References
Original publication: Placental trophoblast cells-derived exosomal microRNA-1290 promotes the interaction between endometrium and embryo by targeting LHX6 Mol Ther Nucl Acids. 2021. DOI: 10.1016/j.omtn.2021.09.009. PMID/PMCID: 34729246; PMC8526418.